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Mechanisms of resistance to immune checkpoint inhibitors

Immune checkpoint inhibitors (ICI) targeting CTLA-4 and the PD-1/PD-L1 axis have shown unprecedented clinical activity in several types of cancer and are rapidly transforming the practice of medical oncology. Whereas cytotoxic chemotherapy and small molecule inhibitors (‘targeted therapies’) largely...

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Bibliografski detalji
Izdano u:Br J Cancer
Glavni autori: Jenkins, Russell W, Barbie, David A, Flaherty, Keith T
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765236/
https://ncbi.nlm.nih.gov/pubmed/29319049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.434
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