Mechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer

BACKGROUND: Reduced RHOA signalling has been shown to increase the growth/metastatic potential of colorectal tumours. However, the mechanisms of inactivation of RHOA signalling in colon cancer have not been characterised. METHODS: A panel of colorectal cancer cell lines and large cohorts of primary...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Dopeso, Higinio, Rodrigues, Paulo, Bilic, Josipa, Bazzocco, Sarah, Cartón-García, Fernando, Macaya, Irati, de Marcondes, Priscila Guimarães, Anguita, Estefanía, Masanas, Marc, Jiménez-Flores, Lizbeth M, Martínez-Barriocanal, Águeda, Nieto, Rocío, Segura, Miguel F, Schwartz Jr, Simo, Mariadason, John M, Arango, Diego
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
Assuntos:
Genetics & Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765235/
https://ncbi.nlm.nih.gov/pubmed/29206819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.420
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