A system for detecting high impact-low frequency mutations in primary tumors and metastases

Tumor complexity and intratumor heterogeneity contribute to subclonal diversity. Despite advances in next-generation sequencing (NGS) and bioinformatics, detecting rare mutations in primary tumors and metastases contributing to subclonal diversity is a challenge for precision genomics. Here, in orde...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Anjanappa, Manjushree, Hao, Yangyang, Simpson, Edward R, Bhat-Nakshatri, Poornima, Nelson, Jennifer B, Tersey, Sarah A, Mirmira, Raghavendra G, Cohen-Gadol, Aaron A, Saadatzadeh, M. Reza, Li, Lang, Fang, Fang, Nephew, Kenneth P., Miller, Kathy D., Liu, Yunlong, Nakshatri, Harikrishna
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5764779/
https://ncbi.nlm.nih.gov/pubmed/28892047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.322
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