Specific oxygenation of plasma membrane phospholipids by Pseudomonas aeruginosa lipoxygenase induces structural and functional alterations in mammalian cells

Pseudomonas aeruginosa is a gram-negative pathogen, which causes life-threatening infections in immunocompromized patients. These bacteria express a secreted lipoxygenase (PA-LOX), which oxygenates free arachidonic acid to 15S-hydro(pero)xyeicosatetraenoic acid. It binds phospholipids at its active...

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Gepubliceerd in:Biochim Biophys Acta
Hoofdauteurs: Aldrovandi, Maceler, Banthiya, Swathi, Meckelmann, Sven, Zhou, You, Heydeck, Dagmar, O'Donnell, Valerie B., Kuhn, Hartmut
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier Pub. Co 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5764228/
https://ncbi.nlm.nih.gov/pubmed/29146531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2017.11.005
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