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Environmental enrichment intervention for Rett syndrome: an individually randomised stepped wedge trial

BACKGROUND: Rett syndrome is caused by a pathogenic mutation in the MECP2 gene with major consequences for motor and cognitive development. One of the effects of impaired MECP2 function is reduced production of Brain Derived Neurotrophic Factor (BDNF), a protein required for normal neuronal developm...

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Bibliografiske detaljer
Udgivet i:Orphanet J Rare Dis
Main Authors: Downs, Jenny, Rodger, Jenny, Li, Chen, Tan, Xuesong, Hu, Nan, Wong, Kingsley, de Klerk, Nicholas, Leonard, Helen
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5764021/
https://ncbi.nlm.nih.gov/pubmed/29321033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13023-017-0752-8
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