N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer’s disease

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder. Amyloid-β (Aβ) aggregation is likely to be the major cause of AD. In contrast to humans and other mammals, that share the same Aβ sequence, rats and mice are invulnerable to AD-like neurodegenerative pathologies, and Aβ of thes...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Kugaevskaya, Elena V., Veselovsky, Alexander V., Indeykina, Maria I., Solovyeva, Nina I., Zharkova, Maria S., Popov, Igor A., Nikolaev, Eugene N., Mantsyzov, Alexey B., Makarov, Alexander A., Kozin, Sergey A.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762728/
https://ncbi.nlm.nih.gov/pubmed/29321566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18567-5
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