LRP6 targeting suppresses gastric tumorigenesis via P14(ARF)–Mdm2–P53-dependent cellular senescence

NLRP6, a member of the Nod-like receptor family, protects against chemically induced intestinal injury and colitis-associated colon cancer. However, the cellular mechanisms involved in this NLRP6-mediated protection remain unclear. Here, we show that NLRP6 was down-regulated in approximately 75% of...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wang, Haibin, Xu, Guoxing, Huang, Zhengjie, Li, Weizheng, Cai, Huali, Zhang, Yunda, Xiong, Disheng, Liu, Gang, Wang, Shengjie, Xue, Zengfu, Luo, Qi
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762345/
https://ncbi.nlm.nih.gov/pubmed/29340077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22876
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