Prexasertib, a cell cycle checkpoint kinases 1 and 2 inhibitor, increases in vitro toxicity of PARP inhibition by preventing Rad51 foci formation in BRCA wild type high-grade serous ovarian cancer

PARP inhibitors (PARPi) have been effective in high-grade serous ovarian cancer (HGSOC), although clinical activity is limited against BRCA wild type HGSOC. The nearly universal loss of normal p53 regulation in HGSOCs causes dysfunction in the G1/S checkpoint, making tumor cells reliant on Chk1-medi...

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Vydáno v:Oncotarget
Hlavní autoři: Brill, Ethan, Yokoyama, Takuhei, Nair, Jayakumar, Yu, Minshu, Ahn, Yeong-Ran, Lee, Jung-Min
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762302/
https://ncbi.nlm.nih.gov/pubmed/29340034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22195
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