Increased efficacy of metformin corresponds to differential metabolic effects in the ovarian tumors from obese versus lean mice

Obesity is a significant risk factor for ovarian cancer (OC) and associated with worse outcomes for this disease. We assessed the anti-tumorigenic effects of metformin in human OC cell lines and a genetically engineered mouse model of high grade serous OC under obese and lean conditions. Metformin p...

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Vydáno v:Oncotarget
Hlavní autoři: Han, Jianjun, Wysham, Weiya Z., Zhong, Yan, Guo, Hui, Zhang, Lu, Malloy, Kim M., Dickens, Hallum K., Huh, Gene, Lee, Douglas, Makowski, Liza, Zhou, Chunxiao, Bae-Jump, Victoria L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762298/
https://ncbi.nlm.nih.gov/pubmed/29340030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20754
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