Inability of positive phase II clinical trials of investigational treatments to subsequently predict positive phase III clinical trials in glioblastoma

BACKGROUND: Glioblastoma is the most common primary malignant brain tumor in adults, but effective therapies are lacking. With the scarcity of positive phase III trials, which are increasing in cost, we examined the ability of positive phase II trials to predict statistically significant improvement...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Mandel, Jacob J, Yust-Katz, Shlomit, Patel, Akash J, Cachia, David, Liu, Diane, Park, Minjeong, Yuan, Ying, Kent, Thomas A, de Groot, John F
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
Assuntos:
Clinical Investigations
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5761583/
https://ncbi.nlm.nih.gov/pubmed/29016865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox144
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