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Intracellular disassembly and activity of pertussis toxin require interaction with ATP
The active subunit (S1) of pertussis toxin (PT), a major virulence factor of Bordetella pertussis, ADP-ribosylates G(i) proteins in the mammalian cell cytosol to inhibit GPCR signaling. The intracellular pathway of PT includes endocytosis and retrograde transport to the trans-Golgi network (TGN) and...
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| Publicado no: | Pathog Dis |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5761283/ https://ncbi.nlm.nih.gov/pubmed/27369899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/femspd/ftw065 |
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