Single, very low rituximab doses in healthy volunteers - a pilot and a randomized trial: implications for dosing and biosimilarity testing

There are no  dose-finding trials available for rituximab that could guide dosing in non-malignant diseases. We hypothesized that currently used doses (≥375 mg/m(2)) exceed several hundred-fold the half-maximal effective dose, which is most sensitive for detecting putative differences between biosim...

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Publicado en:Sci Rep
Main Authors: Schoergenhofer, Christian, Schwameis, Michael, Firbas, Christa, Bartko, Johann, Derhaschnig, Ulla, Mader, Robert M, Plaßmann, Raute Sunder, Jilma-Stohlawetz, Petra, Desai, Kalpna, Misra, Priya, Jäger, Ulrich, Jilma, Bernd
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760686/
https://ncbi.nlm.nih.gov/pubmed/29317666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17934-6
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