Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA

Streptococcus pneumoniae (S.pn.) is the most common bacterial pathogen causing community acquired pneumonia. The pore-forming toxin pneumolysin (PLY) is the major virulence factor of S.pn. and supposed to affect alveolar epithelial cells thereby activating the immune system by liberation of danger-a...

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Publicat a:Sci Rep
Autors principals: Nerlich, Andreas, Mieth, Maren, Letsiou, Eleftheria, Fatykhova, Diana, Zscheppang, Katja, Imai-Matsushima, Aki, Meyer, Thomas F., Paasch, Lisa, Mitchell, Timothy J., Tönnies, Mario, Bauer, Torsten T., Schneider, Paul, Neudecker, Jens, Rückert, Jens C., Eggeling, Stephan, Schimek, Maria, Witzenrath, Martin, Suttorp, Norbert, Hippenstiel, Stefan, Hocke, Andreas C.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760655/
https://ncbi.nlm.nih.gov/pubmed/29317705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18468-7
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