Improved Free-Energy Landscape Quantification Illustrated with a Computationally Designed Protein-Ligand Interaction

Quantifying the energy landscape underlying protein-ligand interactions leads to an enhanced understanding of molecular recognition. A powerful yet accessible single-molecule technique is atomic force microscopy (AFM)-based force spectroscopy, which generally yields the zero-force dissociation rate...

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Detalhes bibliográficos
Publicado no:Chemphyschem
Main Authors: Van Patten, William J., Walder, Robert, Adhikari, Ayush, Okoniewski, Stephen R., Ravichandran, Rashmi, Tinberg, Christine E., Baker, David, Perkins, Thomas T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760306/
https://ncbi.nlm.nih.gov/pubmed/29069529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cphc.201701147
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