System identification of signaling dependent gene expression with different time-scale data

Cells decode information of signaling activation at a scale of tens of minutes by downstream gene expression with a scale of hours to days, leading to cell fate decisions such as cell differentiation. However, no system identification method with such different time scales exists. Here we used compr...

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Publicado en:PLoS Comput Biol
Autores principales: Tsuchiya, Takaho, Fujii, Masashi, Matsuda, Naoki, Kunida, Katsuyuki, Uda, Shinsuke, Kubota, Hiroyuki, Konishi, Katsumi, Kuroda, Shinya
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760096/
https://ncbi.nlm.nih.gov/pubmed/29281625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005913
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