Influences of Anlotinib on Cytochrome P450 Enzymes in Rats Using a Cocktail Method

The present study aimed to investigate the effect of anlotinib (AL3818) on pharmacokinetics of cytochrome P450 (CYP) enzymes (CYP1A2, CYP2C6, CYP2D1, CYP2D2, and CYP3A1/2) by using five cocktail probe drugs in vivo. After pretreatment for 7 days with anlotinib (treatment group) or saline (control gr...

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Bibliografische gegevens
Gepubliceerd in:Biomed Res Int
Hoofdauteurs: Sun, Wei, Wang, Zhe, Chen, Ruimin, Huang, Chengke, Sun, Rui, Hu, Xiaoxia, Li, Wanshu, Chen, Ruijie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Hindawi 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758843/
https://ncbi.nlm.nih.gov/pubmed/29441353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/3619723
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