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Interferon alpha impairs insulin production in human beta cells via endoplasmic reticulum stress
Despite substantial advances in the research exploring the pathogenesis of Type 1 Diabetes (T1D), the pathophysiological mechanisms involved remain unknown. We hypothesized in this study that IFNα participates in the early stages of T1D development by triggering endoplasmic reticulum (ER) stress. To...
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| Publicado no: | J Autoimmun |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5758382/ https://ncbi.nlm.nih.gov/pubmed/28238527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2017.02.002 |
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