Reduced neuroprotective potential of the mesenchymal stromal cell secretome with ex vivo expansion, age and progressive multiple sclerosis

BACKGROUND: Clinical trials using ex vivo expansion of autologous mesenchymal stromal cells (MSCs) are in progress for several neurological diseases including multiple sclerosis (MS). Given that environment alters MSC function, we examined whether in vitro expansion, increasing donor age and progres...

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Bibliographic Details
Published in:Cytotherapy
Main Authors: Sarkar, Pamela, Redondo, Juliana, Kemp, Kevin, Ginty, Mark, Wilkins, Alastair, Scolding, Neil J., Rice, Claire M.
Format: Artigo
Language:Inglês
Published: Elsevier 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758344/
https://ncbi.nlm.nih.gov/pubmed/28917625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcyt.2017.08.007
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