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Progressive calibration and averaging for tandem mass spectrometry statistical confidence estimation: Why settle for a single decoy?

Estimating the false discovery rate (FDR) among a list of tandem mass spectrum identifications is mostly done through target-decoy competition (TDC). Here we offer two new methods that can use an arbitrarily small number of additional randomly drawn decoy databases to improve TDC. Specifically, “Par...

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Bibliographic Details
Published in:Res Comput Mol Biol
Main Authors: Keich, Uri, Noble, William Stafford
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758044/
https://ncbi.nlm.nih.gov/pubmed/29326989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-3-319-56970-3_7
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