Plant-produced anti-dengue virus monoclonal antibodies exhibit reduced antibody-dependent enhancement of infection activity

The mAb E60 has the potential to be a desirable therapeutic molecule since it efficiently neutralizes all four serotypes of dengue virus (DENV). However, mammalian-cell-produced E60 exhibits antibody-dependent enhancement of infection (ADE) activity, rendering it inefficacious in vivo, and treated a...

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Опубликовано в: :J Gen Virol
Главные авторы: Dent, Matthew, Hurtado, Jonathan, Paul, Amber M., Sun, Haiyan, Lai, Huafang, Yang, Ming, Esqueda, Adrian, Bai, Fengwei, Steinkellner, Herta, Chen, Qiang
Формат: Artigo
Язык:Inglês
Опубликовано: Microbiology Society 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5756494/
https://ncbi.nlm.nih.gov/pubmed/27902333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/jgv.0.000635
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