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Enhanced MYC association with the NuA4 histone acetyltransferase complex mediated by the adenovirus E1A N-terminal domain activates a subset of MYC target genes highly expressed in cancer cells

The proto-oncogene MYC is a transcription factor over-expressed in many cancers and required for cell survival. Its function is regulated by histone acetyltransferase (HAT) complexes, such as the GCN5 complex and the NuA4/Tip60 complex. However, the roles of the HAT complexes during MYC function in...

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Dettagli Bibliografici
Pubblicato in:Genes Cancer
Autori principali: Zhao, Ling-Jun, Loewenstein, Paul M., Green, Maurice
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755721/
https://ncbi.nlm.nih.gov/pubmed/29321817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/genesandcancer.160
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