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Impairment of contextual fear extinction by chronic nicotine and withdrawal from chronic nicotine is associated with hippocampal nAChR upregulation

Chronic nicotine and withdrawal from chronic nicotine have been shown to be major modulators of fear learning behavior. Moreover, recent studies from our laboratory have shown that acute nicotine impaired fear extinction and safety learning in mice. However, the effects of chronic nicotine and withd...

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Publicado en:Neuropharmacology
Autores principales: Kutlu, Munir Gunes, Oliver, Chicora, Huang, Peng, Liu-Chen, Lee-Yuan, Gould, Thomas J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755390/
https://ncbi.nlm.nih.gov/pubmed/27378334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2016.06.032
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