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Incretin concept revised: The origin of the insulinotropic function of glucagon‐like peptide‐1 – the gut, the islets or both?

Incretins comprise a pair of gut hormones, glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1), which are secreted in response to food ingestion and enhance glucose‐dependent insulin secretion from pancreatic β‐cells. Immediately after secretion, GLP‐1 is degraded...

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Bibliografske podrobnosti
izdano v:J Diabetes Investig
Main Authors: Yabe, Daisuke, Seino, Yusuke, Seino, Yutaka
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754537/
https://ncbi.nlm.nih.gov/pubmed/28746743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jdi.12718
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