Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

Proinflammatory eicosanoids (prostaglandins and leukotrienes) and specialized pro-resolving mediators (SPM) are temporally regulated during infections. Here we show that human macrophage phenotypes biosynthesize unique lipid mediator signatures when exposed to pathogenic bacteria. E. coli and S. aur...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Werz, Oliver, Gerstmeier, Jana, Libreros, Stephania, De la Rosa, Xavier, Werner, Markus, Norris, Paul C., Chiang, Nan, Serhan, Charles N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754355/
https://ncbi.nlm.nih.gov/pubmed/29302056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02538-5
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