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Intratumoral CD8(+) T-Cell Apoptosis is a Major Component of T-Cell Dysfunction and Impedes Anti-Tumor Immunity
Subsets of human tumors are infiltrated with tumor antigen–specific CD8(+) T cells (TILs) despite tumor progression. These TILs are thought to be inactivated by the immunosuppressive tumor microenvironment, through the engagement of inhibitory receptors such as CTLA-4 and PD-1. However, antigen-spec...
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| Veröffentlicht in: | Cancer Immunol Res |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5754226/ https://ncbi.nlm.nih.gov/pubmed/29097422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0249 |
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