Blocking the VISTA pathway enhances disease progression in (NZB × NZW) F1 female mice

V-domain Ig suppressor of T-cell activation (VISTA) is a critical negative checkpoint molecule involved in regulating the immune response. Targeting the pathway with an antagonist anti-VISTA antibody designated 13F3 has been shown to enhance disease severity in experimental autoimmune encephalomyeli...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Lupus
Main Authors: Sergent, PA, Plummer, SF, Pettus, J, Mabaera, R, DeLong, JK, Pechenick, DA, Burns, CM, Noelle, RJ, Ceeraz, S
Format: Artigo
Jezik:Inglês
Izdano: SAGE Publications 2017
Teme:
Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5753845/
https://ncbi.nlm.nih.gov/pubmed/28659048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0961203317716322
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