Chidamide shows synergistic cytotoxicity with cytarabine via inducing G0/G1 arrest and apoptosis in myelodysplastic syndromes

Chidamide is a newly designed and synthesized histone deacetylase (HDAC) inhibitor that selectively inhibits HDAC 1, 2, 3, and 10. Our previous study demonstrated that chidamide induces G0/G1 arrest and apoptosis in myelodysplastic syndromes (MDS). Low-dose chemotherapy is effective in treating high...

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Detalhes bibliográficos
Publicado no:Am J Transl Res
Main Authors: Liu, Zhaoyun, Chen, Jin, Wang, Honglei, Ding, Kai, Li, Yanqi, de silva, Anya, sehgal, Varun, Burbano, Jonathan lvan, Sundararaj, Radhika, Gamage, Janani, Audu, Victor, Fu, Rong
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752913/
https://ncbi.nlm.nih.gov/pubmed/29312515
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