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PRRT2-dependent dyskinesia: cerebellar, paroxysmal and persistent
In an elegant publication in Cell Research, Tan and colleagues showed that ablation of PRRT2 in cerebellar granule cells is sufficient to induce paroxysmal kinesigenic dyskinesia. PRRT2 turns out to downregulate the presynaptic SNARE complex in granule cell axons, which in turn controls the activity...
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| Udgivet i: | Cell Res |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5752843/ https://ncbi.nlm.nih.gov/pubmed/29148542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.142 |
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