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Inhibition of hepatocellular carcinoma growth by blockade of glycosphingolipid synthesis

Hepatocellular carcinoma (HCC) is one of the most frequent cancers. In vitro studies suggest that growth and response to therapy of human carcinomas may depend on glycosphingolipid (GSL) expression. Glucosylceramide synthase (GCS), encoded by the gene Ugcg, is the basic enzyme required for the synth...

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Foilsithe in:Oncotarget
Main Authors: Jennemann, Richard, Federico, Giuseppina, Mathow, Daniel, Rabionet, Mariona, Rampoldi, Francesca, Popovic, Zoran V., Volz, Martina, Hielscher, Thomas, Sandhoff, Roger, Gröne, Hermann-Josef
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752514/
https://ncbi.nlm.nih.gov/pubmed/29312601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22648
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