Inhibition of hepatocellular carcinoma growth by blockade of glycosphingolipid synthesis

Hepatocellular carcinoma (HCC) is one of the most frequent cancers. In vitro studies suggest that growth and response to therapy of human carcinomas may depend on glycosphingolipid (GSL) expression. Glucosylceramide synthase (GCS), encoded by the gene Ugcg, is the basic enzyme required for the synth...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Jennemann, Richard, Federico, Giuseppina, Mathow, Daniel, Rabionet, Mariona, Rampoldi, Francesca, Popovic, Zoran V., Volz, Martina, Hielscher, Thomas, Sandhoff, Roger, Gröne, Hermann-Josef
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752514/
https://ncbi.nlm.nih.gov/pubmed/29312601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22648
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