Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications

Neurogenic heterotopic ossification (NHO) is the formation of ectopic bone generally in muscles surrounding joints following spinal cord or brain injury. We investigated the mechanisms of NHO formation in 64 patients and a mouse model of spinal cord injury–induced NHO. We show that marrow from human...

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Udgivet i:JCI Insight
Main Authors: Torossian, Frédéric, Guerton, Bernadette, Anginot, Adrienne, Alexander, Kylie A., Desterke, Christophe, Soave, Sabrina, Tseng, Hsu-Wen, Arouche, Nassim, Boutin, Laetitia, Kulina, Irina, Salga, Marjorie, Jose, Beulah, Pettit, Allison R., Clay, Denis, Rochet, Nathalie, Vlachos, Erica, Genet, Guillaume, Debaud, Charlotte, Denormandie, Philippe, Genet, François, Sims, Natalie A., Banzet, Sébastien, Levesque, Jean-Pierre, Lataillade, Jean-Jacques, Le Bousse-Kerdilès, Marie-Caroline
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752299/
https://ncbi.nlm.nih.gov/pubmed/29093266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96034
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