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LRP1 regulates peroxisome biogenesis and cholesterol homeostasis in oligodendrocytes and is required for proper CNS myelin development and repair
Low-density lipoprotein receptor-related protein-1 (LRP1) is a large endocytic and signaling molecule broadly expressed by neurons and glia. In adult mice, global inducible (Lrp1(flox/flox);CAG-CreER) or oligodendrocyte (OL)-lineage specific ablation (Lrp1(flox/flox);Pdgfra-CreER) of Lrp1 attenuates...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5752207/ https://ncbi.nlm.nih.gov/pubmed/29251594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.30498 |
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