A conserved maternal-specific repressive domain in Zelda revealed by Cas9-mediated mutagenesis in Drosophila melanogaster

In nearly all metazoans, the earliest stages of development are controlled by maternally deposited mRNAs and proteins. The zygotic genome becomes transcriptionally active hours after fertilization. Transcriptional activation during this maternal-to-zygotic transition (MZT) is tightly coordinated wit...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Hamm, Danielle C., Larson, Elizabeth D., Nevil, Markus, Marshall, Kelsey E., Bondra, Eliana R., Harrison, Melissa M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752043/
https://ncbi.nlm.nih.gov/pubmed/29261646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007120
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