Complex roles of the stroma in the intrinsic resistance to gemcitabine in pancreatic cancer: where we are and where we are going

Pancreatic ductal adenocarcinoma (PDAC) is among the most devastating human malignancies. The poor clinical outcome in PDAC is partly attributed to a growth-permissive tumor microenvironment. In the PDAC microenvironment, the stroma is characterized by the development of extensive fibrosis, with str...

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Detalhes bibliográficos
Publicado no:Exp Mol Med
Main Authors: Liang, Chen, Shi, Si, Meng, Qingcai, Liang, Dingkong, Ji, Shunrong, Zhang, Bo, Qin, Yi, Xu, Jin, Ni, Quanxing, Yu, Xianjun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750480/
https://ncbi.nlm.nih.gov/pubmed/29611542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2017.255
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