Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury

Hyperhomocysteinemia (HHcy) is a risk factor for various cardiovascular diseases. However, the mechanism underlying HHcy-aggravated vascular injury remains unclear. Here we show that the aggravation of abdominal aortic aneurysm by HHcy is abolished in mice with genetic deletion of the angiotensin II...

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Vydáno v:Nat Commun
Hlavní autoři: Li, Tuoyi, Yu, Bing, Liu, Zhixin, Li, Jingyuan, Ma, Mingliang, Wang, Yingbao, Zhu, Mingjiang, Yin, Huiyong, Wang, Xiaofeng, Fu, Yi, Yu, Fang, Wang, Xian, Fang, Xiaohong, Sun, Jinpeng, Kong, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750214/
https://ncbi.nlm.nih.gov/pubmed/29296021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02401-7
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