Reduced telomere length is associated with fibrotic joint disease suggesting that impaired telomere repair contributes to joint fibrosis

OBJECTIVE: Joint fibrosis affects many synovial joints (including hip, knee and shoulder) causing stiffness and pain. The mechanism of joint fibrosis remains unknown, although genetic factors may contribute. Defects in maintenance of telomere length resulting from impaired telomere repair have been...

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Vydáno v:PLoS One
Hlavní autoři: Kalson, Nicholas S., Brock, Tim M., Mangino, Massimo, Fabiane, Stella M., Mann, Derek A., Borthwick, Lee A., Deehan, David J., Williams, Frances M. K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749754/
https://ncbi.nlm.nih.gov/pubmed/29293561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190120
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