Platelet-mediated shedding of NKG2D ligands impairs NK cell immune-surveillance of tumor cells

Platelets promote metastasis, among others by coating cancer cells traveling through the blood, which results in protection from NK cell immune-surveillance. The underlying mechanisms, however, remain to be fully elucidated. Here we report that platelet-coating reduces surface expression of NKG2D li...

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Détails bibliographiques
Publié dans:Oncoimmunology
Auteurs principaux: Maurer, Stefanie, Kropp, Korbinian Nepomuk, Klein, Gerd, Steinle, Alexander, Haen, Sebastian P., Walz, Juliane S., Hinterleitner, Clemens, Märklin, Melanie, Kopp, Hans-Georg, Salih, Helmut Rainer
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2017
Sujets:
Brief Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749664/
https://ncbi.nlm.nih.gov/pubmed/29308299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1364827
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