Segmented Filamentous Bacteria Provoke Lung Autoimmunity by Inducing Gut-Lung Axis Th17 Cells Expressing Dual TCRs

Lung complications are a major cause of rheumatoid arthritis-related mortality. Involvement of gut microbiota in lung diseases by the gut-lung axis has been widely observed, but the underlying mechanism remains mostly unknown. Using an autoimmune arthritis model, we show that a constituent of the gu...

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Pubblicato in:Cell Host Microbe
Autori principali: Bradley, C. Pierce, Teng, Fei, Felix, Krysta M., Sano, Teruyuki, Naskar, Debdut, Block, Katharine E., Huang, Haochu, Knox, Kenneth S., Littman, Dan R., Wu, Hsin-Jung Joyce
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749641/
https://ncbi.nlm.nih.gov/pubmed/29120746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2017.10.007
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