Cilia loss sensitizes cells to transformation by activating the mevalonate pathway

Although cilia loss and cell transformation are frequently observed in the early stage of tumorigenesis, the roles of cilia in cell transformation are unknown. In this study, disrupted ciliogenesis was observed in cancer cells and pancreatic cancer tissues, which facilitated oncogene-induced transfo...

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Gepubliceerd in:J Exp Med
Hoofdauteurs: Deng, Yue-Zhen, Cai, Zhen, Shi, Shuo, Jiang, Hao, Shang, Yu-Rong, Ma, Ning, Wang, Jing-Jing, Guan, Dong-Xian, Chen, Tian-Wei, Rong, Ye-Fei, Qian, Zhen-Yu, Zhang, Er-Bin, Feng, Dan, Zhou, Quan-Li, Du, Yi-Nan, Liu, Dong-Ping, Huang, Xing-Xu, Liu, Lu-Ming, Chin, Eugene, Li, Dang-Sheng, Wang, Xiao-Fan, Zhang, Xue-Li, Xie, Dong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2018
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748847/
https://ncbi.nlm.nih.gov/pubmed/29237705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170399
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