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Synthesis and In Vitro Cytotoxicity of the 4-(Halogenoanilino)-6-bromoquinazolines and Their 6-(4-Fluorophenyl) Substituted Derivatives as Potential Inhibitors of Epidermal Growth Factor Receptor Tyrosine Kinase

Series of the 2-unsubstituted and 2-(4-chlorophenyl)–substituted 4-anilino-6-bromoquinazolines and their 6-(4-fluorophenyl)–substituted derivatives were evaluated for in vitro cytotoxicity against MCF-7 and HeLa cells. The 2-unsubstituted 4-anilino-6-bromoquinazolines lacked activity, whereas most o...

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書目詳細資料
發表在:Pharmaceuticals (Basel)
Main Authors: Mphahlele, Malose Jack, Paumo, Hugues K., Choong, Yee Siew
格式: Artigo
語言:Inglês
出版: MDPI 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748644/
https://ncbi.nlm.nih.gov/pubmed/29156606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph10040087
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