Hepatocyte-specific deletion of BAP31 promotes SREBP1C activation, promotes hepatic lipid accumulation, and worsens IR in mice

Conditional knockout mice with targeted disruption of B-cell associated protein (BAP)31 in adult mouse liver were generated and challenged with a high-fat diet (HFD) for 36 or 96 days and markers of obesity, diabetes, and hepatic steatosis were determined. Mutant mice were indistinguishable from WT...

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Bibliographische Detailangaben
Veröffentlicht in:J Lipid Res
Hauptverfasser: Xu, Jia-Lin, Li, Li-Ya, Wang, Yan-Qing, Li, Ya-Qi, Shan, Mu, Sun, Shi-Zhuo, Yu, Yang, Wang, Bing
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748495/
https://ncbi.nlm.nih.gov/pubmed/29113994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M077016
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