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Resource limitation prevents the emergence of drug resistance by intensifying within-host competition

Slowing the evolution of antimicrobial resistance is essential if we are to continue to successfully treat infectious diseases. Whether a drug-resistant mutant grows to high densities, and so sickens the patient and spreads to new hosts, is determined by the competitive interactions it has with drug...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Wale, Nina, Sim, Derek G., Jones, Matthew J., Salathe, Rahel, Day, Troy, Read, Andrew F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748215/
https://ncbi.nlm.nih.gov/pubmed/29233945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715874115
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