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Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes

Sclerostin has traditionally been thought of as a local inhibitor of bone acquisition that antagonizes the profound osteoanabolic capacity of activated Wnt/β-catenin signaling, but serum sclerostin levels in humans exhibit a correlation with impairments in several metabolic parameters. These data, t...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Kim, Soohyun P., Frey, Julie L., Li, Zhu, Kushwaha, Priyanka, Zoch, Meredith L., Tomlinson, Ryan E., Da, Hao, Aja, Susan, Noh, Hye Lim, Kim, Jason K., Hussain, Mehboob A., Thorek, Daniel L. J., Wolfgang, Michael J., Riddle, Ryan C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748171/
https://ncbi.nlm.nih.gov/pubmed/29229807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707876115
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