Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo

Thyroid hormone (TH) and TH receptors (TRs) α and β act by binding to TH response elements (TREs) in regulatory regions of target genes. This nuclear signaling is established as the canonical or type 1 pathway for TH action. Nevertheless, TRs also rapidly activate intracellular second-messenger sign...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hönes, G. Sebastian, Rakov, Helena, Logan, John, Liao, Xiao-Hui, Werbenko, Eugenie, Pollard, Andrea S., Præstholm, Stine M., Siersbæk, Majken S., Rijntjes, Eddy, Gassen, Janina, Latteyer, Sören, Engels, Kathrin, Strucksberg, Karl-Heinz, Kleinbongard, Petra, Zwanziger, Denise, Rozman, Jan, Gailus-Durner, Valerie, Fuchs, Helmut, Hrabe de Angelis, Martin, Klein-Hitpass, Ludger, Köhrle, Josef, Armstrong, David L., Grøntved, Lars, Bassett, J. H. Duncan, Williams, Graham R., Refetoff, Samuel, Führer, Dagmar, Moeller, Lars C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748168/
https://ncbi.nlm.nih.gov/pubmed/29229863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706801115
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