Obesity Enhances the Conversion of Adipose-Derived Stromal/Stem Cells into Carcinoma-Associated Fibroblast Leading to Cancer Cell Proliferation and Progression to an Invasive Phenotype

Obesity is associated with enhanced tumor growth and progression. Within the adipose tissue are adipose-derived stromal/stem cells (ASCs) that have been shown to convert into carcinoma-associated fibroblast (CAFs) in the presence of tumor-derived factors. However, the impact of obesity on the ASCs a...

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Veröffentlicht in:Stem Cells Int
Hauptverfasser: Strong, Amy L., Pei, Dorothy T., Hurst, Christian G., Gimble, Jeffrey M., Burow, Matthew E., Bunnell, Bruce A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748106/
https://ncbi.nlm.nih.gov/pubmed/29527228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/9216502
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