Differentiation and cell density upregulate cytochrome c levels in megakaryoblastic cell lines: Implications for analysis of CYCS-associated thrombocytopenia

Mutations in the cytochrome c gene (CYCS) cause autosomal dominant thrombocytopenia by an unknown mechanism. While attempting to generate megakaryoblastic cell lines exogenously expressing cytochrome c variants, we discovered that endogenous cytochrome c expression increased both upon induction of d...

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Vydáno v:PLoS One
Hlavní autoři: Ong, Lily, McDonald, Kirstin O., Ledgerwood, Elizabeth C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5747465/
https://ncbi.nlm.nih.gov/pubmed/29287084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190433
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