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Biosensor Technology Reveals the Disruption of the Endothelial Barrier Function and the Subsequent Death of Blood Brain Barrier Endothelial Cells to Sodium Azide and Its Gaseous Products

Herein we demonstrate the sensitive nature of human blood-brain barrier (BBB) endothelial cells to sodium azide and its gaseous product. Sodium azide is known to be acutely cytotoxic at low millimolar concentrations, hence its use as a biological preservative (e.g., in antibodies). Loss of barrier i...

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Detalhes bibliográficos
Publicado no:Biosensors (Basel)
Main Authors: Kho, Dan T., Johnson, Rebecca H., O’Carroll, Simon J., Angel, Catherine E., Graham, E. Scott
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746764/
https://ncbi.nlm.nih.gov/pubmed/28934106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/bios7040041
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