SM22α suppresses cytokine-induced inflammation and the transcription of NF-κB inducing kinase (Nik) by modulating SRF transcriptional activity in vascular smooth muscle cells

Vascular smooth muscle cell (VSMC) phenotypic modulation is characterized by the downregulation of SMC actin cytoskeleton proteins. Our published study shows that depletion of SM22α (aka SM22, Transgelin, an actin cytoskeleton binding protein) promotes inflammation in SMCs by activating NF-κB signal...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Dai, Xiaohua, Thiagarajan, Devi, Fang, Jingye, Shen, Jianbin, Annam, Neeraja Priyanka, Yang, Zhao, Jiang, Hong, Ju, Donghong, Xie, Youming, Zhang, Kezhong, Tseng, Yan Yuan, Yang, Zhe, Rishi, Arun K., Li, Hui J., Yang, Maozhou, Li, Li
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746259/
https://ncbi.nlm.nih.gov/pubmed/29284006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190191
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