Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells

Cancer cells frequently exhibit chromosomal abnormalities. Specific cytogenetic aberrations often are predictors of outcome, especially in hematologic neoplasms, such as monosomy 7 in myeloid malignancies. The functional consequences of aneuploidy at the cellular level are difficult to assess becaus...

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Gepubliceerd in:Blood
Hoofdauteurs: Zhao, Xin, Gao, Shouguo, Wu, Zhijie, Kajigaya, Sachiko, Feng, Xingmin, Liu, Qingguo, Townsley, Danielle M., Cooper, James, Chen, Jinguo, Keyvanfar, Keyvan, Fernandez Ibanez, Maria del Pilar, Wang, Xujing, Young, Neal S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2017
Onderwerpen:
Myeloid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746166/
https://ncbi.nlm.nih.gov/pubmed/29030335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-08-803353
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