Organotypic three-dimensional cancer cell cultures mirror drug responses in vivo: lessons learned from the inhibition of EGFR signaling

Complex three-dimensional (3D) in vitro models that recapitulate human tumor biology are essential to understand the pathophysiology of the disease and to aid in the discovery of novel anti-cancer therapies. 3D organotypic cultures exhibit intercellular communication, nutrient and oxygen gradients,...

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Pubblicato in:Oncotarget
Autori principali: Jacobi, Nico, Seeboeck, Rita, Hofmann, Elisabeth, Schweiger, Helmut, Smolinska, Veronika, Mohr, Thomas, Boyer, Alexandra, Sommergruber, Wolfgang, Lechner, Peter, Pichler-Huebschmann, Corina, Önder, Kamil, Hundsberger, Harald, Wiesner, Christoph, Eger, Andreas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746077/
https://ncbi.nlm.nih.gov/pubmed/29296175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22475
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