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Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci

Glucocorticoids act by binding to the glucocorticoid receptor (GR), which binds to specific motifs within enhancers of target genes to activate transcription. Previous studies have suggested that GRs can promote interactions between gene promoters and distal elements within target loci. In contrast,...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Jubb, Alasdair W., Boyle, Shelagh, Hume, David A., Bickmore, Wendy A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cell Press 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745231/
https://ncbi.nlm.nih.gov/pubmed/29241532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.11.053
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